IMMUNE CHECKPOINT INHIBITOR PD-1 PATHWAY IS DOWN-REGULATED IN SYNOVIUM AT VARIOUS STAGES OF RHEUMATOID ARTHRITIS DISEASE PROGRESSION.

Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.

Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multiple cancer types, concomitant with immune-related adverse events, including arthralgia and inflammato

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Cross-sectional evaluation of medical reversals among National Institute of Health guideline practices implemented during the COVID-19 pandemic: how often did experts err in a time of crisis?

Objective The COVID-19 pandemic required the rapid and often widespread implementation of medical practices without robust data.Many of these practices have since been tested in large, randomised trials and were found to be in error.We sought to identify incorrect recommendations, or reversals, among National Institute of Health COVID-19 guidelines

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